RESOLUTION NO. _____________

BOARD OF SUPERVISORS, COUNTY OF SAN MATEO, STATE OF CALIFORNIA

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RESOLUTION 1) AUTHORIZING THE EXECUTION OF AN AGREEMENT WITH PPD DEVELOPMENT, LP TO CONDUCT A CLINICAL RESEARCH STUDY TO EVALUATE THE EFFICACY AND SAFETY OF CLEVUDINE COMPARED TO ADEFOVI IN TREATING PATIENTS WITH HBEAG POSITIVE CHRONIC HEPATITIS DUE TO HEPATITIS B VIRUS, AND 2) AUTHORIZING THE EXECUTION OF AN AGREEMENT WITH PPD DEVELOPMENT, LP TO CONDUCT A CLINICAL RESEARCH STUDY TO EVALUATE THE EFFICACY AND SAFETY OF CLEVUDINE COMPARED TO ADEFOVI IN TREATING PATIENTS WITH HBEAG NEGATIVE CHRONIC HEPATITIS DUE TO HEPATITIS B VIRUS, AND 3) AUTHORIZING THE CHIEF EXECUTIVE OFFICER OF SAN MATEO MEDICAL CENTER OR THE CEO’S DESIGNEE TO EXECUTE CONTRACT AMENDMENTS TO EITHER OR BOTH OF THE AGREEMENTS WHICH MODIFY THE COUNTY’S MAXIMUM FISCAL OBLIGATION BY NO MORE THAN $25,000 (IN AGGREGATE), AND/OR MODIFY THE CONTRACT TERM AND/OR SERVICES SO LONG AS THE MODIFIED TERM OF SERVICES IS/ARE WITHIN THE CURRENT OR REVISED FISCAL PROVISIONS

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RESOLVED, by the Board of Supervisors of the County of San Mateo, State of California, that

 

WHEREAS, a preliminary assessment by the San Mateo Medical Center’s Clinical Trials and Research Unit identified Hepatitis B as a health issue affecting many of the County’s patients who are not responding to the current drug treatments; and

 

WHEREAS, on March 2008, PPD Development, LP requested that the Clinical Trials and Research Unit participate in two clinical research studies that would explore new drug treatments for SMMC patients with Hepatitis B; and

 

WHEREAS, the parties now wish to enter into two Agreements pursuant to which the County’s Clinical Trials and Research Unit will participate in both studies for a period of 96 weeks from the date Agreements are fully executed, in an amount to be paid to the County not to exceed $106,468.75 per Agreement; and

 

WHEREAS, there has been presented to this Board of Supervisors for its consideration and acceptance, forms of Agreement, reference to which is hereby made for further particulars, whereby the County will participate in the two clinical research studies to evaluate the efficacy and safety of Clevudine compared to Adefovi in treating patients with HBeAG Positive due to Hepatitis B Virus and in treating patients with HBeAG Negative Chronic Hepatitis due to Hepatitis B Virus; and

 

WHEREAS, this Board has examined and approved both Agreements as to form and content and desires to enter into them

 

NOW, THEREFORE, IT IS HEREBY DETERMINED that the President of this Board of Supervisors be, and is hereby authorized and directed to execute said Agreements for and on behalf of the County of San Mateo, and the Clerk of this Board shall attest the President's signatures thereto.

BE IT FURTHER RESOLVED that the Chief Executive Officer of San Mateo Medical Center or the CEO’s designee shall be authorized to execute contract Amendments to either or both of the Agreements which modify the County’s maximum fiscal obligation by no more than $25,000 (in aggregate), and/or modify the contract term and/or services so long as the modified term of services is/are within the current or revised fiscal provisions.

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